Transcriptomic and Metabolomic Profiling of Chicken Adipose Tissue: Dual Purpose Benefit for Human Obesity and Poultry Production
Beckford, R. C., E. Tague, S. R. Campagna, and B. H. Voy.  2017.  Current Metabolomics, in press.

Domestic chickens are a valuable yet underutilized set of model organisms for studies relevant to human obesity and adipose metabolism. Chickens and humans share similarities in adipose tissue lipid metabolism, and the in ovo development of the chick enables studies of adipose development that are difficult to perform in other organisms. Fundamental understanding of adipose biology is also important for the poultry industry because broiler (meat-type) chickens are prone to obesity due to consequences of genetic selection for rapid growth. Transcriptomic and metabolomic studies have begun to characterize adipose metabolism in chickens, yielding important insight into mechanisms that control adipose deposition and of leanness. These findings are relevant for both understanding obesity in humans, and for addressing the excess deposition of adipose tissue that plagues commercial broiler production. This review highlights what has been learned about the molecular basis for adipose deposition in chickens using a combination of transcriptomics and metabolomics.